Mix-and-match COVID vaccines: the case is growing but questions remain

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Thank you for visiting nature. A mixture of two COVID vaccines could provide a similar immune response to two doses of a single vaccine. Mixing COVID vaccines is emerging as a good way to get people the protection they need when faced with safety concerns and unpredictable supplies. Most vaccines against SARS-CoV-2 must be given in two doses, but multiple studies now back up the idea that mixing the Oxford—AstraZeneca jab and the Pfizer—BioNTech vaccine triggers an immune response similar to — or even stronger than — two doses of either vaccine. Results announced on Monday 1 by a UK group suggest that the combination sometimes outperforms two shots of the same vaccine, and a similar picture is emerging from German studies 23. But at least 16 vaccines have been approved for use in one or more countries, and mix-and-match studies so far have been small, so more extensive trials and long-term monitoring for side effects are sorely needed. Mix-and-match studies were prompted, in large part, by concerns over the safety of the vaccine developed by the University of Oxford and pharmaceutical company AstraZeneca in Cambridge, both in the United Kingdom. The jab has been associated with rare instances of a blood-clotting condition known as thrombosis with thrombocytopaenia — and in March, some European countries decided to halt its use in some groups of people.

Be grateful you for visiting nature. Countries along with fluctuating supplies of COVID vaccines could benefit from using different vaccines designed for the first and second dose. Beginning results from the trial of add than people — announced in an online presentation on 18 May 1 — are the first to act the benefits of combining different coronavirus vaccines. A UK trial of a similar strategy reported 2 safety fact last week, and is expected en route for deliver further findings on immune responses soon. Because of safety concerns, a number of European countries are already recommending so as to some or all people who were given a first dose of the vaccine developed by the University of Oxford, UK, and AstraZeneca in Cambridge, UK, get another vaccine for their second dose.

Be able to someone get their initial COVID vaccine from one manufacturer and then acquire a booster from another? Allowing ancestor to mix and match COVID shots could significantly improve vaccine distribution after that may even offer some medical benefits. This afternoon an advisory committee en route for the U. Food and Drug Admin will review data from a contemporary National Institutes of Health study so as to seeks to answer the question. The preliminary results of this very diminutive study hint that the answer can be yes. If the FDA finally endorses mixing brands, the decision could help nationwide vaccination efforts, says Pedro Piedra, professor of molecular virology, microbiology, and pediatrics at Baylor College of Medicine in Houston. Doctors and pharmacists would also benefit, says Robert M. Jacobson, medical director of the basic care immunization program at the Mayo Clinic. This would reduce waste, as more people could be inoculated as of each open vial, he notes.

UK, remember your settings and improve administration services. This page applies to England. If the names are different, acquaintance your GP practice to have your details updated. If you have not been fully vaccinated, you should carry on to follow the entry requirements of the country you are travelling en route for, such as proof of a damaging COVID test on arrival. You should carefully research the requirements of your destination country before travelling. Further details on entry requirements can be bring into being on the GOV. UK foreign go advice pages and on the websites of your destination country. See assistance about travelling abroad from England all through the pandemic.

After that then came Delta. And it additionally spurred a full-on freak-out that our understanding of who could spread the virus was all wrong. The aimed implication of that finding was constant more ominous: Vaccinated people were a minute ago as likely to spread the bug as the unvaccinated. Three months afterwards, we have fortunately not seen this doomsday scenario come to pass—the fears raised by the Provincetown report were largely overblown. Breakthrough infections are allay happeningand they can lead to broadcast. Vaccinated people spread the virus a lesser amount of overall because they are significantly a lesser amount of likely to get infected in the first place. But there are a load of reasons to be optimistic afar that. He pointed me to two studies, neither of which has been peer-reviewed, to make his point. All the rage the other study, researchers in the United Kingdom found that the Pfizer and AstraZeneca vaccines consistently reduced broadcast downstream of breakthrough cases.

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